Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study.
Identifieur interne : 001579 ( Main/Exploration ); précédent : 001578; suivant : 001580Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study.
Auteurs : Z A Memish [Arabie saoudite] ; J A Al-Tawfiq ; H Q Makhdoom ; A A Al-Rabeeah ; A. Assiri ; R F Alhakeem ; F A Alrabiah ; S. Al Hajjar ; A. Albarrak ; H. Flemban ; H. Balkhy ; M. Barry ; S. Alhassan ; S. Alsubaie ; A. ZumlaSource :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Arabie saoudite (épidémiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Dépistage systématique, Facteurs sexuels, Famille, Femelle, Humains, Infection croisée (diagnostic), Infection croisée (épidémiologie), Infections à coronavirus (diagnostic), Infections à coronavirus (épidémiologie), Jeune adulte, Mâle, Personnel de santé (), Réaction de polymérisation en chaine en temps réel, Surveillance de la population.
- MESH :
- diagnostic : Infection croisée, Infections à coronavirus.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- épidémiologie : Arabie saoudite, Infection croisée, Infections à coronavirus.
- Adolescent, Adulte, Dépistage systématique, Facteurs sexuels, Famille, Femelle, Humains, Jeune adulte, Mâle, Personnel de santé, Réaction de polymérisation en chaine en temps réel, Surveillance de la population.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Adolescent, Adult, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Cross Infection (diagnosis), Cross Infection (epidemiology), Family, Female, Health Personnel (statistics & numerical data), Humans, Male, Mass Screening, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Population Surveillance, Real-Time Polymerase Chain Reaction, Saudi Arabia (epidemiology), Sex Factors, Young Adult.
- MESH :
- geographic , epidemiology : Saudi Arabia.
- diagnosis : Coronavirus Infections, Cross Infection.
- epidemiology : Coronavirus Infections, Cross Infection.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- statistics & numerical data : Health Personnel.
- Adolescent, Adult, Family, Female, Humans, Male, Mass Screening, Population Surveillance, Real-Time Polymerase Chain Reaction, Sex Factors, Young Adult.
Abstract
The Saudi Arabian Ministry of Health implemented a pro-active surveillance programme for Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV). We report MERS-CoV data from 5065 Kingdom of Saudi Arabia individuals who were screened for MERS-CoV over a 12-month period. From 1 October 2012 to 30 September 2013, demographic and clinical data were prospectively collected from all laboratory forms received at the Saudi Arabian Virology reference laboratory. Data were analysed by referral type, age, gender, and MERS-CoV real-time PCR test results. Five thousand and 65 individuals were screened for MER-CoV: hospitalized patients with suspected MERS-CoV infection (n = 2908, 57.4%), healthcare worker (HCW) contacts (n = 1695; 33.5%), and family contacts of laboratory-confirmed MERS cases (n = 462; 9.1%). Eleven per cent of persons tested were children (<17 years of age). There were 108 cases (99 adults and nine children) of MERS-CoV infection detected during the 12-month period (108/5065, 2% case detection rate). Of 108 cases, 45 were females (six children and 39 adults) and 63 were males (three children and 60 adults). Of the 99 adults with MERS-CoV infection, 70 were hospitalized patients, 19 were HCW contacts, and ten were family contacts. There were no significant increases in MERS-CoV detection rates over the 12-month period: 2.6% (19/731) in July 2013, 1.7% (19/1100) in August 2013, and 1.69% (21/1238) in September 2013. Male patients had a significantly higher MERS-CoV infection rate (63/2318, 2.7%) than females (45/2747, 1.6%) (p 0.013). MERS-CoV rates remain at low levels, with no significant increase over time. Pro-active surveillance for MERS-CoV in newly diagnosed patients and their contacts will continue.
DOI: 10.1111/1469-0691.12562
PubMed: 24460984
Affiliations:
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We report MERS-CoV data from 5065 Kingdom of Saudi Arabia individuals who were screened for MERS-CoV over a 12-month period. From 1 October 2012 to 30 September 2013, demographic and clinical data were prospectively collected from all laboratory forms received at the Saudi Arabian Virology reference laboratory. Data were analysed by referral type, age, gender, and MERS-CoV real-time PCR test results. Five thousand and 65 individuals were screened for MER-CoV: hospitalized patients with suspected MERS-CoV infection (n = 2908, 57.4%), healthcare worker (HCW) contacts (n = 1695; 33.5%), and family contacts of laboratory-confirmed MERS cases (n = 462; 9.1%). Eleven per cent of persons tested were children (<17 years of age). There were 108 cases (99 adults and nine children) of MERS-CoV infection detected during the 12-month period (108/5065, 2% case detection rate). Of 108 cases, 45 were females (six children and 39 adults) and 63 were males (three children and 60 adults). Of the 99 adults with MERS-CoV infection, 70 were hospitalized patients, 19 were HCW contacts, and ten were family contacts. There were no significant increases in MERS-CoV detection rates over the 12-month period: 2.6% (19/731) in July 2013, 1.7% (19/1100) in August 2013, and 1.69% (21/1238) in September 2013. Male patients had a significantly higher MERS-CoV infection rate (63/2318, 2.7%) than females (45/2747, 1.6%) (p 0.013). MERS-CoV rates remain at low levels, with no significant increase over time. Pro-active surveillance for MERS-CoV in newly diagnosed patients and their contacts will continue.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li></country></list><tree><noCountry><name sortKey="Al Hajjar, S" sort="Al Hajjar, S" uniqKey="Al Hajjar S" first="S" last="Al Hajjar">S. Al Hajjar</name><name sortKey="Al Rabeeah, A A" sort="Al Rabeeah, A A" uniqKey="Al Rabeeah A" first="A A" last="Al-Rabeeah">A A Al-Rabeeah</name><name sortKey="Al Tawfiq, J A" sort="Al Tawfiq, J A" uniqKey="Al Tawfiq J" first="J A" last="Al-Tawfiq">J A Al-Tawfiq</name><name sortKey="Albarrak, A" sort="Albarrak, A" uniqKey="Albarrak A" first="A" last="Albarrak">A. Albarrak</name><name sortKey="Alhakeem, R F" sort="Alhakeem, R F" uniqKey="Alhakeem R" first="R F" last="Alhakeem">R F Alhakeem</name><name sortKey="Alhassan, S" sort="Alhassan, S" uniqKey="Alhassan S" first="S" last="Alhassan">S. Alhassan</name><name sortKey="Alrabiah, F A" sort="Alrabiah, F A" uniqKey="Alrabiah F" first="F A" last="Alrabiah">F A Alrabiah</name><name sortKey="Alsubaie, S" sort="Alsubaie, S" uniqKey="Alsubaie S" first="S" last="Alsubaie">S. Alsubaie</name><name sortKey="Assiri, A" sort="Assiri, A" uniqKey="Assiri A" first="A" last="Assiri">A. Assiri</name><name sortKey="Balkhy, H" sort="Balkhy, H" uniqKey="Balkhy H" first="H" last="Balkhy">H. Balkhy</name><name sortKey="Barry, M" sort="Barry, M" uniqKey="Barry M" first="M" last="Barry">M. Barry</name><name sortKey="Flemban, H" sort="Flemban, H" uniqKey="Flemban H" first="H" last="Flemban">H. Flemban</name><name sortKey="Makhdoom, H Q" sort="Makhdoom, H Q" uniqKey="Makhdoom H" first="H Q" last="Makhdoom">H Q Makhdoom</name><name sortKey="Zumla, A" sort="Zumla, A" uniqKey="Zumla A" first="A" last="Zumla">A. Zumla</name></noCountry><country name="Arabie saoudite"><noRegion><name sortKey="Memish, Z A" sort="Memish, Z A" uniqKey="Memish Z" first="Z A" last="Memish">Z A Memish</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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